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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2004, Vol. 9 ›› Issue (3): 249-252.

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Animal models of Alzheimer's disease and their evaluation

WANG Ying-Yan, HUANG Ren1, WANG Hui   

  1. Department of Pharmacology, Guangdong Medical College, Zhanjiang 514023, Guangdong, China;
    1Guangdong Laboratory Animals Monitoring Institute, Guangzhou 510260,Guangdong, China
  • Received:2003-08-11 Revised:2003-11-20 Online:2004-03-26 Published:2020-11-21

Abstract: Alzheimer's disease (AD)is a kind of disease in nervous system.A good models is very important in the research of prevention and remedy.The present progress of these models were reviewed, and the merits and defeats were evaluated.The researches of AD have acquired a few of staged achievements, but no critical breakthrough.The road leads to perfect models is long still.

Key words: Alzheimer's disease, disease model, transgenic animals, senescence accelerated mouse, neuronfibrillary tangles, senile plague, amyliod protein

CLC Number: