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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2004, Vol. 9 ›› Issue (3): 253-256.

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Antihypertensive characteristics of combination of iptakalim and pinacidil,potassium channel openers

WANG Gui-Ying1, LONG Chao-Liang, WANG Hai   

  1. Institute of Pharmacology and Toxicology, Academy of Millitary Medical Sciences, Beijing 100850, China;
    1Department of Physiology, Institute of Basic Medical Sciences, Hebei Medical University, Shijiazhuang 050091, Hebei, China
  • Received:2003-11-08 Revised:2004-01-18 Online:2004-03-26 Published:2020-11-21

Abstract: AIM: To study the antihypertensive characteristics of Iptakalim (Ipt) and pinacidil (Pin), the potassium channel openers (KCOs) of aliphatic amines and guanidine monohydrate, respectively.METHODS: The conscious noninvasive method with tail cuff was performed in rats to record the systolic blood pressure (SBP) and HR.RESULTS: SBP decreased and HR increased prominently in a dose-dependent manner after treatment with Pin at the doses of 2.0 and 4.0 mg·kg-1.While treated with Ipt at the doses of 2.0, 4.0 and 8.0 mg·kg-1under the same experimental conditions, SBP decreased but HR had no significant change.When administered with Ipt and Pin simultaneously, SBP decreased synergistically, and the effects on elevating HR were equal to that of Pin.CONCLUSION: Antihypertensive characteristics of Ipt are different from that of Pin, and the antihypertensive effects can be strengthened by combination of Pin and Ipt.

Key words: potassium channel openers, pinacidil, iptakalim, blood pressure, heart rate

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