Abstract: AIM: To observe the effects of amygdalin in immunoloregulation.METHODS: Subcutaneous injection of Freund adjuvant resulted in atrophic gastritis models in rats, and then the free and total acidity and activity of pepsin in gastric juice were determined after ig amygdalin for 6 months.Intradermal injection of Freund adjuvant caused adjuvant arthrositis in rats after ig amygdalin for 7 d, and then inflammatory swelling of primary inflammatory and swelling percentage (%)and inhibition percentage (%) of recurrent inflammatory were determined as well as the indexes of clearance (K)and phagocytosis (α)by the carbon granular clearance in mice after ig amygdalin for 7 d.RESULTS: The activity of pepsin in high dose group and middle dose group decreased (P <0.05).The acidity of gastric juice of all groups had no significant difference (P >0.05).Amygdalin could prevent adjuvant arthrositis in rats, and high andmiddle dose of amygdalins could inhibit inflammatory swelling (P < 0.01).K and αincreased (P <0.01)in high dose group, but K increased in middle dose group (P < 0.05).CONCLUSION: Amygdalin can regulate immunological function in animal models.

Key words: amygdalin, atrophic gastritis, adjuvant arthrositis, carbon granular clearance