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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2004, Vol. 9 ›› Issue (3): 299-301.

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Effects of a novel phosphodiesterase IV inhibitor Ariflo on endothelin-1-induced contractility of isolated human uterine myometrium

QI Hong, Leroy MJ1, Advenier C2, ZHANG Yong, Emmanuel N2, CHEN Hong-Zhuang   

  1. Department of Pharmacology, Shanghai Second Medical University, Shanghai 200025, China;
    1INSERM, U-361, Paris, France;2University Paris Ⅴ, Rene Descartes, Pari s, France
  • Received:2003-09-08 Revised:2004-02-18 Online:2004-03-26 Published:2020-11-21

Abstract: AIM: To investigate the effects of selective phosphodiesterase (PDE)IV inhibitor Ariflo on the contractility of nonpregnant human uterine myometrium induced by endothelin-1 (ET-1).METHODS: Contractile responses to Ariflo were accumulated in isolated human myometrium.RESULTS: Ariflo could inhibit both the frequency and amplitude of autonomic contraction of myometrium (pD2 =7.90)and ET-1 induced contraction in a concentration-dependent manner (pD2 =7.40), with a potency similar to that of Rolipram.CONCLUSION: Ariflo has the effect of inhibition on endothelin-1-induced contractility of the isolated human uterine myometrium evidently.

Key words: phosphodiesterase IV inhibitor, endothelin-1, uterine myometrium, dysmenorrhea, rolipram

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