Abstract: AIM: To study the protective effect of diaminonium glycyrrhizinate (DG) on cyclophosphamide (CP) injured rats.METHODS: The experiments were randomly divided into 3 DG groups, the normal group and the control group.After administered ig 0.5 %DG (20, 40, 60 mg·kg^-1) or equal amount of distilled water to rats for 9 d, the control group and DG groups were given CP (150 mg·kg^-1) once a day on the 6th, 7th and 8th day.The Level of white blood cell (WBC), red blood cell (RBC), platelet (PLT), total protein (TP), globulin (GLO), albumin (ALB) and the content of malondial-hydride(MDA) produced by lipid peroxidatio in heart, liver, and kidney tissue were observed respectively.The values of coagulation time of blood in each group were examined.RESULTS: DG obviously inhibited the decrease of WBC, RBC, PLT, TP, GLO, and ALB, and the content of MDA was also decreased in heart, kidney and liver tissue.CONCLUSION: DG protects the rats from cyclophosphamide injured.

Key words: diaminonium glycyrrhizinate (DG), white blood cell, total protein, coagulation time, malondial-hydride