Effects of new ATP-sensitive potassium channel pener iptakalim on Parkinsonian symptoms induced by haloperidol in rats

Abstract

Abstract: AIM: To investigate the effects of the new K_ATP channel opener, I_ptakalim (I_pt), on the Parkinsonian symptoms induced by haloperidol in rats. METHODS: Using L-DOPA as the positive drug, the influences of I_pt on latency time, walking time, rearing and grooming of the parkinsonian-like rats induced by haloperidol were observed.RESULTS: I_pt ameliorated hypolocomotion and assuaged catalepsy induced by haloperidol in rats. Moreover, the effects of I_pt (0.5 mg·kg^-1) were better than those of L-DOPA (100 mg·kg^-1).CONCLUSION: Opening of K_ATP channels may play a key role in improving Parkinsonian symptoms induced by haloperidol in rats.

Key words: ATP-sensitive potassium channel, opener, iptakalim, haloperidol, parkinsonian symptoms

CLC Number:

R965.1

LONG Yan, YANG Yong, DING Jian-Hua, HU Gang. Effects of new ATP-sensitive potassium channel pener iptakalim on Parkinsonian symptoms induced by haloperidol in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(4): 378-381.

References

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