Abstract: AIM: To compare pharmacokinetic character between zinc gluconate (Zn-G)and zinc fructose-1, 6-diphosphate(Zn-FDP)in mice.METHODS: Inductively coupled plasma (ICP)was used to measure the zinc serum concentration at regular time-points in mice, and the pharmacokinetic parameters of both drugs were calculated. RESULTS: The values of Ke (h^-1)of Zn-FDP and Zn-G were 0.27 ±0.12 and 0.41 ±0.03, respectively;the t_max(h), 1.65 ±0.04 and 1.43 ±0.05;the C_max (mg·L^-1), 9.27 ±0.25 and 13.46 ±0.16;and AUC (mg·h^-1·L^-1), 47.45 ±2.11 and 57.67 ±5.80. CONCLUSION: The blood zinc content after Zn-FDP orally administered is lower than that one after Zn-G, but there is no significance in the zinc content differences among heart, liver, brain and kidney, suggesting that Zn-FDP is not as good as Zn-G in absorption.

Key words: zinc gluconate, zinc fructose-1, 6-diphosphate, pharmacokinetics, inductively coupled plasma (ICP)