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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2004, Vol. 9 ›› Issue (4): 434-437.

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Protective effects of deproteinized extract of calf blood on hypoxia-reoxygenation-induced injury in cultured myocardial cells

YANG Yu-Hong, LOU Feng-Xia, WANG Hong-Xin   

  1. Department of Pharmacology, Jinzhou Medical College, J inzhou 121001, Liaoning, China
  • Received:2003-12-02 Revised:2004-02-06 Online:2004-04-26 Published:2020-11-20

Abstract: AIM: To explore the effects of DECB (deproteinized extract of calf blood, DECB) on hypoxiareoxygenation-induced injury in cultured cardiac myocytes.METHODS: By using cultured myocardial cells as models, thenumber of death cells, beating frequency and the content of LDH were observed after hypoxia-reoxygenation-induced injury. RESULTS: 0.1 and 0.3 g·L-1 of DECB decreased the number of death cells and the content of lactate dehydrogenase (LDH), and restored the cellular beating frequency in the supernatant. CONCLUSION: DECB can protect the cultured myocardial cells against hypoxia-reoxygenation-induced injury.

Key words: myocardial cells, cultured, deproteinized extract of calf blood, hypoxia-reoxygenation-induced injury

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