Abstract: AIM: To study the pharmacokinetics of diclofenac sodium sustained-released suppository in healthy volunteers.METHODS: A single dose of 100 mg diclofenac sodium sustained-released suppository was given to 20 healthy volunteers.The concentrations of diclofenac sodium sustained-released suppository in plasma were determined by HPLC method.The parameters of pharmacokinetics were calculated by 3p87 program.RESULTS: The C_max of the drug was 1.1 ±0.310 mg·L ^-1; T_max was 1.7 ±0.167 h;T_1/2(ke) was 2.3 ±0.6 h;CL was 27 ±6 L·h ^-1;V_d was 74 ±25 L;AUC_0-∞ was 4.0 ±1.2 mg·h ^-1·L ^-1.CONCLUSION: The pharmacokinetics of this drug in healthy volunteers can be fitted into one compartment model with 1st order absorption.

Key words: diclofenac sodium, sustained-released sppository, pharmacokinetics, HPLC, plasma