Abstract: AIM: To study the pharmacokinetics of the nano red elemental selenium (Nse) in Beagle dogs. METHODS: Blood levels of selenium were determined before and different times after administration.The observed values and increased values (observed value plus baseline) of blood levels of selenium were used to calculate pharmacokinetic parameters. RESULTS: Nse conformed to one-compartment model with fast absorption and slow elimination.T_{1 2} was 34.2 h by observed values in calculation and 20 h by increased values. CONCLUSION: Nse leads to toxicity easily in the administration with long term and large dose.For the material with baseline in body, the pharmacokinetic analysis should use the increased values to calculate parameters.

Key words: pharmacokinetics, nano red elemental selenium, selenium, Beagle dogs