Abstract: AIM: To evaluate the safety and efficiency of oral anticoagulation in patients with transient ischemic attack (TIA). METHODS: The hospitalized patients with TIA were treated by oral anticoagulation according to Roberts'age adjustedWarfarin loading protocol from February of 2003 for 12 months.The cases in control group were those with TIA except those having been used heparin from February of 2002 till January of 2003. RESULTS: Compare the two groups with average age, rate of gender, rate of cases complicated cardiac disease, hypertension and diabetes, blood pressure, cholestein, and triglyceride.There was no significant difference in all general conditions between two groups (P >0.05).However, there was no patient with the anticoagulation to develop stroke and hemorrhage in following days, but there were 6 cases had acute ischemic stroke in control group after that (P <0.05). CONCLUSION: Oral anticoagulation by using Roberts'Warfarin dosing guidelines is safe and more effective in patients with TIA.

Key words: transient ischemic attack (TIA), warfarin, loading dose, anticoagulation