Effects of ketamine on cumulative survival in septic mice induced by cecal ligation and puncture

Abstract

Abstract: AIM: To investigate the dose-related effects of ketamine on cumulative survival in mice models of polymicrobial sepsis induced by cecal ligation and puncture (CLP).METHODS: Mice with CLP were divided randomly into four groups, received ketamine injection intraperitoneally of 0, 3, 6, and 12 mg·100 g^-1, respectively, at 1 and 6 h after CLP.The survival rate was observed in each group.RESULTS: No change in mortality was observed after 72 hours among four groups.Ketamine administration was associated with significant improvement of the survival of mice with CLP (P<0.05), especially in 6 mg·100 g^-1 group (P<0.05).CONCLUSION: Ketamine administration dose-independently delays lethality from sepsis in mice with CLP.

Key words: ketamine, cecal ligation and puncture, sepsis, mice, cumulative survival

CLC Number:

R971.2

LIU Fen, CHEN Jin-He, LI Sheng-Hua, ZHAO Wen-Hui, AI Yong-Xun. Effects of ketamine on cumulative survival in septic mice induced by cecal ligation and puncture[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(8): 942-944.

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