Abstract: AIM: To evaluate the efficiency and safety of compound polydimethylsiloxane chewable tablets (CPCT)in treatment of patients with some acute gastrointestinal symptoms.METHODS: CPCT was observed in the multi-center, randomized, double-blind, double-simulated and paralleled-control clinical trail.138 patients with two or over two acute gastrointestinal symptoms were divided into two groups (n=69 in each):the trial group which was treated with CPCT 2 tablets, fourth a day, and the control group which was treated with native hydrotalcid tablet 2 tablets, forth a day.The duration of treatment for both groups was 7 days.RESULTS: The cure rates in trial group and control groups were 33.3 % and 36.2 %, respectively.The total effective rates in trial group and control groups were 85.5 % and 89.8 %, respectively. There was no significant difference between two groups (P>0.05).The adverse drug reaction rates were 4.35 % and 1.45 %, respectively, and there was no significantly statistical differences between two groups.CONCLUSION: Both CPCT and native hydrotalcid tablet has the same efficiency and safety in the treatment of some gastrointestinal symptoms.CPCT is a kind of effective and safe drug.

Key words: compound polydimethylsiloxane chewable tablets, hydrotalcid tablets, clinical trials, efficiency, safety