Relationship between Glutathione and related enzymes and multidrug resistance

Abstract

Abstract: Multidrug resistance to chemotherapeutic drugs is an important reason for clinieal chemotherapy failure. The mechanisms of the classical drug resistancesuch as P-gp, MRP have been clarified. Hence, it isvery important to further study the non-classical mechanism of multidrug resistance. We introduced the effects on MDR, the possible mechanisms of glutathione and relatedenzymes, as well as the relationship between structure of GSH analogues and the transport activity in this paper

Key words: multidrug resistance, glutathione, relat-enzymes, transporter, transport mechanism: analogs

CLC Number:

R979.1

JIANG Yi, LI Yun-man. Relationship between Glutathione and related enzymes and multidrug resistance[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(10): 1086-1091.

References

1 冯丹,刘云鹏. GST-π与恶性肿瘤多药耐药的研究进展[J].肿瘤防治杂志,2004;11:663-5
2 钟清木,叶韵斌,张其忠.谷胱甘肽及其相关酶系统与肿瘤多药耐药的关系[J].福建医科大学学报,2000;34(增刊);7-9
3 Burg D, Filippov DV,Hennanns R, van der Marel GA, van Boom JH,Mulder GJ. Peptidormimetic glutathione analogues as novel gamma GT stable GST inhibitors[J]. Bioorg Med Chem, 2002;10:195-205
4 Tatebr S, Unate H, Sinicrope FA, Sakatani T, Sugamura K, MakinoM, et al. Expression of heavy subunit of gamma-glu-tamylcysteine synthetase (garmma-GCSh) in human colorectal rarcinoma[J]. Int J Cancer, 2002;97:21-7
5 孔肇路,金一牌,BSO增强MRP过表达肺癌细胞对顺铂敏感性的作用机制研究[J].中国癌症杂志,2004;14:5-8
6 lewandowicz GM,Britt P, Elgie AW,Williamson CJ, Coley HM, Hall AG, el al. Cellular glutathione content, in vitro chemore-sponse, and the effect of BSO modulation in sarmples derived from patients with advanced ovarian cancer[J]. Gynecol Oncol,2002;85:298-304
7 曾晓勇,叶章群,杨为民,陈忠.人膀胱癌耐药细胞株原癌基因c-jun、c-fos表达与y-谷氨酰半胱氨酸合成酶及谷胱甘肽的关系[J].肿瘤防治研究,2004;31:30-2
8 曾晓勇,杨为民,叶章群,张旭,刘继红,陈忠.原癌基因C-jun.c-fos与人膀胱癌耐药细胞株谷胱甘肽及其多药耐药基因表达的关系[J].华中科技大学学报(医学版),2004;33:173-9
9 Shukla GS, Shukla A, Potts RJ, Osier M,Hart BA, Chiu JF. Cad-mium-mediated oxidative stress in alverolar epithelial cells induc-es the expresion of gamma glutamylcysteine synthetase catalytic subunit and glutathione S-transferase alpha and pi isoforms: po-tential role of activator protein[J]. Cell Biol Toxicol, 2000;16:347-62
10 曾晓勇,叶章样,杨为民,陈忠,刘继红,张旭,AP-1反义寡聚脱氧核茌酸逆转人膀胱癌耐药细胞多药耐药的实验研究[J].中华实验外科杂志,2004;21:565-7
11 Rappa G,Lorico A, Hildinger M, Fodstad O, Baum C. Novel bi-cistronic retroviralvector expressing gamma glutamylcysteine synthetase and the multidrug resistance protein 1(MRP) pro-tects cells from MRP fluxed drugs and alkylating agents[J].Hum Gene Ther, 2001;12:1785-96
12 Galloway DC, Blake DG, Shepherd AG, McI ellan LI. Regula-tion of human Y-glutamyl-cysteine synthetase: co-ordinate induc-tion of the catalytic and regulatory Subunits in HepG2 cells[J].Biochem J, 1997;328(Ptl):99-104
13 Bernardini S, Bernassola F, Cortese C, Ballerini S, Melino G,Motti C, et al. Modulation of GST P1-1 activity by polymeriza-tion during apoptosis[J]. J Cell Biochem, 2000;77:645-53
14 Homolya L, Varadi A, Sarkadi B.Multidug resistance associated proteins: Export pumps for conjugates with glutathione, glucur-onate or sulfatel[J]. Biofactors, 2003;17:103-14
15 林安华.多药耐药相关蛋白与肿瘤多药耐药性[J].医学综述,2004;10:11-4
16 Sharma R, Singhal S, Cheng J, Yang Y,Sharma A, Zimniak P,et al.RLIP76 Is the major ATP-Dependent transporter of gluta-thione conjugates and doxorubicin in human erythrocytes([J].Arch Biochem Biophys, 2001;391:171-9
17 Ren XQ, Furukawa т, Aoki S, Nakajima т, Sunizawa т, Hara-guchi м, et al. Glutathione-dependent biding of a phtafinity tanalog of agosterol A to the с terminal half of human multidrug resistance protein[J].J Biol Chem, 2001;276:23197-206
18 Ren XQ, Furukawa T, Aoki s, Sumizawa T, Haraguchi M,Che XF, et al. Localization of the GSH-dependent photolabel-ling site of an agosterol A analog on hurman MRP,[J]. Br J Phar-macol, 2003;138:1553-61
19 Mao Q, Qiu W, Weigl KE, Lander PA, Tabas LB, Shepard RL.et al. GSH-dependent Photolabeling of Multidrug Resis-tance Protein 1 MRP, (ABCCI) by [1251]LY475776. Evidenceof a major binding site in the COOH-proximalmembrane span-ning domain[J]. J Biol Chem, 2002;277: 28690-9
20 Qian YM, Grant CE, Westlake CJ, Zhang DW, Lander PA, Shepard RL, et al. Photolabeling of human and murine Multi-drug Resistance Protein with the High affinity inhibitor [¹²⁵I]LY475776 and azidophenacyl-[35S] glutathione[J]. J Biol Chem, 2002; 277: 35225-31
21 Ren XQ. Furukawa T, Nakajima Y, Takahashi H, Aoki S, Sunizawa T, et al. GSH inhibits trypsinization of the C-terminalhalf of human MRP,[J].J Biol Chem, 2005;280:6231-7
22 Leslie EM,Bowers RJ, Deeley RG, Cole SP. Structural requirements for functional interaction of glutathione tripeptide analogs with the human Multidrug Resistance Protein I (MRP₁)[J]. J Pharmacol Exp Ther,2003;304;643-53
23 Loe DW, Deeley RG, Cole SP. Characterization of vincristine transport by the 190 kDa multidrug resistance protein, MRP: evidence for co-transport with reduced glutathione[J]. Cancer Res, 1998;58:5130-6

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