Antitumor activities of extracts from Stellera chamaejasmel L by various polarity of solvent extraction in vitro

Abstract

Abstract: AIM: To find the optimal polarity zone by comparing the antitumor effects of various polarity solvent extracts.METHODS: The various polarity solvent was used to separate the plant dry powder (petroleum mether, acetate, acetone, and ethanol) The antitumor activities of the different extracts on human cancer cell lines in witro were analyzed using MTT assay.RESULTS: The petroleum ether extract and the ethyl acetate extract strongly inhibited the proliferation of leukemia K562 cells, oesopnagus cancer Eca109 cells and hepato careinoma HepG₂ cells, and showed significant dose-dependent response while thele acetone extract and the ethanolextract exhibited low antitumor activities in wtro. The petroleum ether extract was the most active part.CONCLUSION: The petroleum ether extract is the principalantitumor extract from Stellera chanraeiasmel L.

Key words: Stellera chamaejasmel: various polarity solvent extract, MTT, antitumor activity, petroleum ether extract

CLC Number:

R979.1

LUO Hui-ying, WANG Ai-qin. Antitumor activities of extracts from Stellera chamaejasmel L by various polarity of solvent extraction in vitro[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(10): 1140-1142.

References

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