Effects of isoproterenol on myocardial fibrosis and related cytokines in rats

Abstract

Abstract: AIM: To study the effects of isoproterenol(Iso on cardiac fibrosis and related cytokines in rats.METHODS: 20 SD rats were divided into control and Isgroup in random, with 10 rats each group. After injectedIso, cardiac histology was observed and cardiac function collagen volume fraction (CVF), content of collagen protein and the concentrations of Angiotensin II (Angll) andnitrogen monoxide (NO were measured in the two groups.RESULTS: Compared with control group, mi) scopic examination Showed that fibrosis Increased In Iso group. Iso did decrease cardiac function and NO levelsand increase CVF, content of collagen protein and Anglllevels. Left ventricular pressure maximal rate of rise (+dp/dt_max) and left ventricular systolic pressure (LVSP) were not significantly different from that of control group.CONCLUSIONS: Iso can induce myocardial fibrosis andchange levels of related cytokines in rats.

Key words: isoproterenol, myocardial fibrosis, ratsangiotensin II, nitrogen monoxide

CLC Number:

R965.1

ZHANG Ling, WANG Hong-xin. Effects of isoproterenol on myocardial fibrosis and related cytokines in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(10): 1186-1189.

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