Abstract: AIM: To explore the difference of efficacy between omeprazole and otherdrugs in treatment of active peptic ulcerand bleeding.METHODS: The efficacy of omeprazole orotherdrugs in treatment of active peptic ulcerand bleeding was analyzed by Meta-analysis in homogeneity test and combined test in 9 studies.RESULTS: Homogeneity test showed that the cited studies were homogeneous withχ² =9.84,P>0.05;and in combined test,the combined Or=4.42 and its 95 %confidence interval was in 2.83-6.68 (χ²=44.4,P<0.01).CONCLUSION: Omeprazole is a very effective and well-tolerated proton pumPinhibitorand it is worthy of being recommended foradministration in patients with active peptic ulcerand bleeding.

Key words: active peptic ulcerand bleeding, omeprazole, Meta-analysis, clinical trial