Abstract: AIM: To study the inhibition effects of seal oil on fatty liver in rats.METHODS: A low dose of carbon tetrachloride and high fat diet chronically feed was given to five groups (n =10 in each) of male Wistar rats for 7 weeks to induce the model of fatty liver. Then the five groupswere orally administered olive oil, simvastatin 4 mg°kg^-1°d^-1, seal oil 0.5, 1.6 or 4.8 g°kg^-1°d^-1 for other 8 weeks, respectively. The untreated control group received only normal feed.The liver lipid, produc-tion of prostacyclin and thromboxane A₂, lipid superoxi-dation parameters were measured to compare with the changes.The pathology was evaluated. RESULTS: The ratio of 6-keto-PGF_1α/TXB₂ were significantly increased in seal oil group due to decrease TXB₂ and increase 6-keto-PGF_1α in liverwhen compared with those in olive oil group (model group) (P<0.01). Liver TC, TG, FFA and MDA concentrations were significantly decreased in the seal oil groupswhen compared with those in model group (P<0.01), but SOD concentration increased (P< 0.01). Pathology showed that seal oil markedly improved fatty liver and the reduction of index analyzed from CYP2E1 express (P<0.01). CONCLUSION: Seal oil inhibits fatty changes of the liver by both direct effects of inhibition the synthesis of liver lipid and modulating lipid metabolism and indirect effects of increase the hepatic blood flow due to decrease the TXA₂ concentration and blood viscosity. In addition, seal oil shows anti-lipid su-peroxidation by decreasing MDA concentration.

Key words: seal oil, fatty liver, liver lipid, TXA₂, PGI, MDA