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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2005, Vol. 10 ›› Issue (5): 532-536.

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Effects of 3,4,5, 6-tetrahydroxyxanthone on myocardial ischemia-reperfu-sion injury in isolated rat hearts

DAI Zhong, HU Chang-ping1, WU Tie, DAI Bin, LIN Xi   

  1. Department of Pharmacology, Guangdong Medical College, Zhanjiang 524023, Guangdong, China;
    1Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha410078, Hunan, China
  • Received:2005-03-09 Revised:2005-04-25 Online:2005-05-26 Published:2020-11-19

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Abstract: AIM: To study the protective effects and mechanisms of 3, 4, 5, 6-tetrahydroxyxanthone on myocar-dial ischemia-reperfusion injury in isolated rat hearts. METHODS: Ischemia-reperfusion injury was induced by 30 min of global ischemia and 30 min of reperfusion in isolated rat hearts.Heart rate, coronary flow (CF), left ventricular pressure (LVP), and the first derivative (+ dp/dtmax) were recorded.The activity of creatine kinase in coronary effluent and tumor necrosis factor-alpha (TNF-α) content in myocardial tissues were measured. RESULTS: 3, 4, 5, 6-tetrahydroxyxanthone (30, 100 or 300 μmol°L-1) caused a significant improvement of car-diac function and a decrease in the release of creatine ki-nase in coronary effluent as well as the level of TNF-αin myocardial tissues.CONCLUSION: 3, 4, 5, 6-tetra-hydroxyxanthone possesses a protective effect onmyocardi-al ischemia-reperfusion injury, and the effects may be re-lated to inhibition of TNF-αproduction.

Key words: 3,4,5,6-tetrahydroxyxanthone, myo-cardial ischemia-reperfusion, tumor necrosis factor-alpha

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