Abstract: AIM: To investigate the determinants of the efficacy of famciclovir in treatment of patients with herpes zoster.METHODS: The patients were adminis-tered famciclovir 250 mg, three times a day for 7 days. Logistic regression was used for investigate the factors. RESULTS: The correlations of cure rate and effective rate with some factors were negative. Those factors in-cluded age, number of lesions (papules/vesicles), time to stop new vesicles, time to loss of acute phase pain, time to appear crusting, time to full crusting, inducer, total score before treatment. But some factors such as gender, location of lesions, ulcers, erythema, score of pain were not effect on the efficacy. CONCLUSION: Some factors such as age, number of lesions (papules vesicles), time to stop new vesicles, time to loss of acute phase pain, time to appear crusting, time to full crusting, inducer, total score before treatment show important influ-ences on the efficacy of famciclovir in treatment of patients with herpes zoster.

Key words: famciclovir, herpes zoster, efficacy, Logistic regression, determinant