Abstract: AIM: To compare pharmacokinetics and bioavailability of different felodipine sustained-release tablets in healthy volunteers.METHODS: Drug concen-trations were determined in plasma following a single oral dose of 5 mg felodipine sustained-release tablets by high performance liquid chromatography method. Referenced with the general felodipine tablets, pharmacokinetics and bioavailability were calculated and compared. RESULTS: Good linear relationship between felodipine con-centration was obtained at ranges of 0.5 -10μg°L^-1 in plasma and the peak-high.Pharmacokintic parameters were different clearly for different felodipine sustained-re-lease tablets in healthy volunteers, and bioavailability ref-erenced with the general felodipine tablets were 168%, 177%and 125%, respectively. CONCLUSION: There are difference at pharmacokintics and bioavailability among those three felodipine sustained-release tablets.

Key words: felodipine, sustained-release tablets, pharmacokinetics, bioavailability, high performance liquid chromatography