Abstract: AIM: To explore the protective effects of compound oral liquid xinkang on the acute myocardial in-jury. METHODS: The rats were divided into four groups:control group, sport group, Tau group and Ts group.9 groups of rats were taking compound oral liquid xinkang of different ingredient, and the swimming time was observed.Exosomatic heart model of Wistar ratswere divided into three groups:control group, A/R group and xinkang group. Heart function index, CPK activity, MDA, GSH-PX, SOD and myocardial microscopic struc-ture were observed.The ventricular myocardial cells of 1 -3 days old SD rats were divided into three groups.In control group, the cells were cultivated with reperfusion liquid.In A/R group, the cells were cultivated with an-oxia/reperfusion liquid.In xinkang group, the cells were first cultivated with xinkang oral liquid and second with anoxia/reperfusion liquid. Myocardial survival ratio, LDH activity in cultivating liquid and myocardial microscopic structure were observed. RESULTS: Swimming time in Tau and Ts groupwere longer than that in sport group (P<0.05). Serum CPK in Tau and Ts group were lower than that in sport group (P<0.05). Taurine influenced the swimming time much more than salvia miltiorrhiza. Taurine of high concentration and salvia miltiorrhiza of middle concentration were better. LVSP, dp/dt max and HR in control group were steady during perfusion, but those in A Rgroupwere decreased during perfusionfor 5, 10, 20 and 30 min (P<0.01), and those in xinkang group were higher than those in control group during per-fusion for 5, 10, 20 and 30 min (P<0.01). In A/R group, myocardial enzyme activity was lower, and MDA and CPK were higher than those in control group (P< 0.01). The results were inverse contrast xinkang group with A R group.Myocardial microscopic structure in con-trol groupwas normal, and that in A R group was serious-ly destroyed. The structure in xinkang group was im-proved. Myocardial survival ratio in A/R group was lower than that in control group (P<0.01). The ratio in xin-kang group was higher than that in A/R group (P< 0.01). LDH activity in A/R group was higher than that in control group (P<0.01). The activity in xinkang group was lower than that in A/R group (P<0.01). Myocardial microscopic structure in control groupwas nor-mal, and that in A/R group was seriously destroyed.The structure in xinkang group was improved.CONCLUSION: Oral liquid xinkang compounded of taurine and salvia miltiorrhiza can protect the myocardium experienced anoxia/reperfusion.

Key words: taurine, salvia miltiorrhiza, myocardi-um, anoxia/reperfusion, rats