Abstract: AIM: To observe the effects of the guanxinning tablets on platelet aggregation, blood coagu-lation and vascular endothelial secretion function in qi stagnation and blood stasis rats.METHODS: Rats were treated with high (1.2 g°kg^-1), middle (0.6 g°kg^-1) and low (0.3 g°kg^-1) doses of guanxinning for fifteen days, and then qi stagnation and blood stasis rat model was established by adrenalin subcutaneous injection and ice water immersion.Spontaneous platelet aggregation and adhesion rate, prothrombin time (PT), thromboplastin time (TT), activated partial thromboplastin time (APTT), level of plasma thromboxane B₂ (TXB₂), 6-Ke-to-PGF_1α, nitric oxide (NO), endothelin (ET), content of MDA and activity of serum superoxide dismutase (SOD) were determined. RESULTS: Spontaneous platelet aggregation and adhesion rate in guanxinning rats was remarkably descended.PT, TT, APTT content of NO and TXB₂ in plasma were elevated significantly, the content of MDA in serum was increased and activity of SOD was re-duced obviously. And the content of ET in plasma was decreased obviously, and the rate of (TXB₂) to 6-Keto-PGF_1α in plasma was digressive. CONCLUSION: Guanxinning contributes to inhibit platelet aggregation and blood coagulation in rat models, to boost elimination for free radical, and to improve secretion function of vascular ehdothelial cells.

Key words: blood stasis, rats, platelet aggregation, vasculuar endothelium