Discussion on basic request and standardization in safety pharmacology

Abstract

Abstract: Safety pharmacology is an integrated discipline that has evolved from the distinct fields of pharmacology, physiology and toxicology.Safety pharmacology studies identify, monitor and characterize potentially undesirable pharmacodynamic activities in non-or pre-clinical studies.In this paper the actuality of safety pharmacology is analyzed, the basic request of experiment design is discussed, and the standardization of design for the experiment of central nervous system, cardiovascullar system and respiratory system is discussed.

Key words: safety pharmacology, toxicology, experiment design, pharmacological method, general pharmacology

CLC Number:

SHI Hong, LU Yan-ping, QIAN Bo-chu. Discussion on basic request and standardization in safety pharmacology[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(9): 961-965.

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