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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2005, Vol. 10 ›› Issue (9): 988-991.

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Experimental studies on antitumor effects of nobiletin in vivo and in vitro

GE Hui, CHENG Mei-ying, ZHANG Hong-quan   

  1. Medical and Pharmaceutical Academy of Yangzhou University, Yangzhou 225001, Jiangsu, China
  • Received:2005-07-21 Revised:2005-09-01 Published:2020-11-22

Abstract: AIM: To study the anti-tumor effect of nobiletin in vivo and in vitro.METHODS: The models of S180, BGC-823 and EAC inmice were established.Tumor growth inhibitory rates and EAC survival rate were calculated.The growth of two tumor cell lines (K562, HL-60) was observed with MTT assay in vitro.RESULTS: Nobiletin inhibited the proliferation of S180 and BGC-823 at the inhibitory rates of 39.11%-55.67% and 36%-58%, and prolong the life span of EAC mice at survival rate of 15.38%-24.61%.Nobiletin possessed inhibitory activity on the growth of K562 and HL-60 in vitro, the inhibitory rates increase in concentration and time dependent manners of in dose range of 2.5-10 μg·ml-1.CONCLUSION: Nobiletin can not only inhibit the growth of tumor cell lines, including S180, BGC-823, K562, and HL-60, but also prolong the life span of EAC mice.

Key words: nobiletin, anti-tumor, transplanted tumor, MTT, tumor inhibitory rate

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