Abstract: AIM:To investigate the therapeutic ef- fects of Milkvetch injection in neonates with hypoxic isch- emic encephalopathy ( HIE ) .METHODS:Neonates with HIE were randomly divided into two routine group( n =30) and a Milketch treatment group ( n =30) .NBNA were done at different time session and the dynamic levels of MDA in serum were investigated at the time of admis- sion, the 3 d and 7 d .RESULTS:The grades at the third day in traditional group were 8 .67 ±2 .50, which had no statistical significance compared with Milkvetch group ( 8 .27 ±2 .53) ( P >0 .05) .There had significant difference ( 25 .47 ±8 .27 vs 32 .40 ±5 .86) between them at the seventh day ( P <0 .01) .The differences of MDA levels between traditional and Milkvetch group be- fore treatment ( 4 .96 ±0 .37 vs 5 .00 ±0 .38) showed no statistical significance but there were marked difference between the two groups at the third day ( 7 .28 ±0 .86 vs 6 .18 ±0 .79) and seventh day ( 6 .43 ±0 .79 vs 5 .43 ± 0 .64) ( P <0 .05) .CONCLUSION:Milkvetch can significantly decrease abnormally elevatory MDA serum levels of neonates with HIE and improve the NBNA grades, and have the neuroprotective effect .

Key words: neonate, hypoxic-ischemic encephalopa- thy , Milkvetch , MDA , NBNA , neuroprotective effect