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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2006, Vol. 11 ›› Issue (1): 14-21.

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Progress in anti-multidrug resistance mediated by p-glycoprotein

MA Bing-liang , WU Yu-lin1 , LIU Guo-qing2   

  1. Department of Pharmacology , Shanghai University of Traditional Chinese Medicine , Shanghai 201203 , China ; 1Depart- ment of Physiology , 2Department of Pharmacology , China Pharmaceutical University , Nanjing 210038 , Jiangsu ,China
  • Received:2005-09-15 Revised:2005-10-31 Online:2006-01-06 Published:2020-10-23

Abstract: P-glycoprotein (P-gp)plays an important role in multidrug resistance (MDR).This article was fo- cused on the protein structure and the mechanism of P- gp , and especially on the current status in anti-P-gp drug research and discovery .The action of P-gp in MDR was also reviewed .Moreover , the potential adverse reaction of P-gp inhibitors were emphasized since P-gp was involved in the normal function of a lot of organs .

Key words: p-glycoprotein ;multidrug resistance, inhibitors ;gene expression

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