Extraction of anti-CPG ODN component from Terminaliachebula retz and their activity evaluation

Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2006, Vol. 11 ›› Issue (1): 59-61.

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Extraction of anti-CPG ODN component from Terminaliachebula retz and their activity evaluation

YAO Jie , ZHENG Jiang , JIANG Dong-neng , LU Yong-ling , WEI Li-zhao

Medical Reseach Center, Southwest Hospital , Third Military Medical University , Chongqing 400038 , China

Received:2005-09-06 Revised:2005-11-05 Online:2006-01-06 Published:2020-10-23

Abstract

Abstract: AIM:To extract different components from Terminaliachebula retz and evaluate their anti-CPG ODN activities .METHODS :Anti- CPG ODN fractions were extracted through water extraction and ion-exchange HPLC.Their binding activities to CPG ODN were select- ed through sensor technology .Their inhibiting activity to the release of TNF-αfrom RAW 264 .7 was determined . RESULTS :Three anti-CPG ODN fractions were extract- ed from Terminaliachebula ret .Terminaliachebula retz 3 fraction was proved to have most powerful binding activity to CPG ODN , and inhibit the release of TNF-αof RAW 264 .7 .CONCLUSION:The Terminaliachebula retz 3 fraction has marked anti-CPG ODN activity .

Key words: Terminaliachebula retz ;anti-CPG ODN , active fraction ;sensor technology

CLC Number:

R965 .1

YAO Jie , ZHENG Jiang , JIANG Dong-neng , LU Yong-ling , WEI Li-zhao. Extraction of anti-CPG ODN component from Terminaliachebula retz and their activity evaluation[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(1): 59-61.

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Extraction of anti-CPG ODN component from Terminaliachebula retz and their activity evaluation

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