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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2006, Vol. 11 ›› Issue (11): 1270-1274.

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Effect of simvastatin on non-neuronal M cholinoceptor of rabbit aorta endothelium with hyperlipemia

LI Jun, WANG Qian, WANG Ru-huan, LONG Chao-liang, WANG Hai   

  1. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
  • Received:2006-04-27 Revised:2006-06-30 Online:2006-11-26 Published:2020-11-06

Abstract: AIM: To investigate the effect of simvastatin on non-neuronal M3 mRNA expression of rabbit aorta with hyperlipemia.METHODS: Hype rlipemia rabbit model was induced by high lipid diet.The simvastatin grouPwas treated with 5 mg·kg-1 everyday for 15 weeks.Endothelium dependent relaxation responses to acetylcholine( ACh) and non-endothelium dependent relaxation responses to nitroprusside ( SNP) of thoracic aortic rings were measured respectively.The M3 mRNA expression of aorta endothelium were tested by RT-PCR.RESULTS: Compared with the hyperlipemia group, simvastatin treatment significantly degraded the plasma lipid concentration,attenuated the inhibition of endothelium dependent relaxation induced by hyperlipemia and improved the mRNA expression of M3 in aorta endothelium.CONCLUSION: Simvastatin can reverse M3 mRNA expression of aorta endothelium reduced by hyperlipemia and improve the vasodilatory activity.

Key words: non-neuronal M cholinoceptor, hyperlipemia, endothelium, vasodilation, simvastatin

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