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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2006, Vol. 11 ›› Issue (3): 332-335.

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Meta-analysis of effectiveness and safety of granisetron for preventing chemotherapy-induced nausea

SHI Qing-ping, SANG Ran   

  1. Department of Pharmacy,Affiliated Hospital of Bengbu Medical College,Bengbu 233004,Anhui,China
  • Received:2005-12-03 Revised:2006-01-06 Online:2006-03-26 Published:2020-12-04

Abstract: AIM: To compare the differences in the effectiveness and safety between granisetron and other drugs for preventing chemotherapy-induced nausea.METHODS: The effectiveness and safety between granisetron and other drugs for preventing chemotherapy-induced nausea were analyzed by Meta-analysis in homogeneity test and combined test.RESULTS: Homogeneity test showed that the cited studies of efficacy and safety were homogeneous withχ2=28.57,χ2=26.19,P>0.05,respectively.In combined test,the combined OR=1.879,OR=0.760 and its 95% confidence interval was in 1.453-2.431,0.122-0.605,respectively.CONCLUSION: The effectiveness of granisetron in treating chemotherapy-induced nausea is significantly superior to those of the medications used at present and the rate of side effects was low.

Key words: granisetron, chemotherapy-induced nausea, safety, efficacy, Meta-analysis

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