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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2006, Vol. 11 ›› Issue (6): 629-633.

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Clinical evaluation of prescription salvia miltiorrhiza and ginkgo biloba in treating hyperlipemia

HE Guo-rong, QI Bei1, YU Li-ping2, HU Wen-li3, DU Guan-hua   

  1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;
    1Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing 100091, China;
    2Heart Centre, Beijing Chaoyang Hospital, Affiliate of Capital University of Medical Sciences, Beijing 100020, China;
    3Department of Neurology, Beijing Chaoyang Hospital, Affiliate of Capital University of Medical Sciences, Beijing 100020, China
  • Received:2006-04-20 Revised:2006-06-02 Online:2006-06-26 Published:2020-12-04

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Abstract: AIM: To compare the curative effect of simvastatin, xuezhikang and prescription of salvia miltiorrhiza and ginkgo biloba (SMGB) in hyperlipemia.Methods: Three hundred and ten patients with hyperlipemia were randomly divided intofour groups.Patients in the placebo group (n=30)were administered 2 capsules thrice daily.Patients in simvastatin group (n=50) were given 20 mg of the drug at bed time.Patients in xuezhikang group (n=50)were administered 2 capsules of the drug twice daily.Patients in the prescription of SMGB group (n=180)received 2 tablets of the drug twice daily.The course of treatment in each of the 4 groups lasted 12 weeks.Seventy patients in the prescription of SMGB group were treated for 24 weeks.Results: Of one hundred and eighty patients in the prescription of SMGB group, total cholesterol (TC)and triglyceride (TG)were decreased significantly.Low-density lipoprotein (LDL-C) was decreased similarly compared to the other two groups. High-density lipoprotein (HDL-C)was elevated as treatment time was prolonged.Conclusion: The prescription of SMGB has curative effect and safety comparable to xuezhikang and simvastatin.The side effects were minimal even after treatment with prescription of SMGB for half a year.

Key words: salvia miltiorrhiza and ginkgo biloba, simvastatin, xuezhikang, hyperlipemia, lipid treatment

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