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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2006, Vol. 11 ›› Issue (9): 972-977.

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Advances in mechanism on insulin-like actions of vanadium

ZHANG Ling, LI Da-wei, XIA Zuo-li, LI Qing1   

  1. Research Institute of Basic Medical Science , Taishan medical College , taian 271000 , Shandong , China;
    1Department of School Health Care , Shandong Agriculture University , Taian 271018 , Shandong , China
  • Received:2006-04-17 Revised:2006-05-28 Online:2006-09-26 Published:2020-11-05

Abstract: The insulin-mimetic effect of vanadium is the most remarkable and important function among its several biological actions.Basing on the lots of representative literatures, this review summarized the researching background, development and acting mechanisms on the insulin-mimetic effects of vanadium.The key mechanisms involved are inhibition of protein-phosphotyrosine phosphatases and activation of nonreceptor protein-tyrosine kinases,in an insulin-receptor tyrosine kinase independent fashion.

Key words: vanadium, insulin, biological function

CLC Number: