Progress and research in pharmacogenetics of oral antidiabetic drugs

Abstract

Abstract: Diabetes mellitus is a metabolic disease influenced by numerous genes and environmental factors. The genetic polymorphisms of drug-metabolizing enzymes, transporters or receptors play very important roles in the metabolism and therapeutical efficacy of oral antidiabetic drugs.In this review, we summarized the effects of genetic polymorphisms of certain CYP450 enzymes, transporters or receptors on the drug metabolism and efficacy of oral antidiabetic drugs including sulfonylureas, thiazolidinediones, meglitinide analogues, biguanides and α-glucosaccharase inhibitors.

Key words: diabetes mellitus, drug response, polymorphism, CYP450, receptor, transporter

CLC Number:

R587.1
R968

ZHANG Wei, WANG An, ZHOU Hong-hao. Progress and research in pharmacogenetics of oral antidiabetic drugs[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(1): 7-10.

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