Progress of signal transduction pathway of gastrin stimulating proliferation of colorectal carcinoma cells

Abstract

Abstract: Recent studies indicate that there are expressions of gastrin and its receptors in the tissue and cell line of colorectal cancer. Gastrin stimulates the proliferation of colorectal carcinoma as well as inhibits the apoptosis of colorectal carcinoma so as to promote the growth and invasion of colorectal carcinoma via a series of signal transduction pathways induced by its specific receptors. To inhibit the abnormally active signal transduction pathways that stimulate the proliferation of colorectal carcinoma will provide a new effective measure for the prevention and management of colorectal carcinoma. But the accurate signal transductions are not clear and need further research.

Key words: gastrin, signal transduction pathway, colorectal cancer

CLC Number:

R735.3

ZHAO Ying-chun, WU Pei. Progress of signal transduction pathway of gastrin stimulating proliferation of colorectal carcinoma cells[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(11): 1221-1225.

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