Herb-drug interactions in oncology and potential mechanisms

Abstract

Abstract: An increasing number of cancer patients are using complementary and alternative medicines (CAM) in combination with their conventional chemotherapeutic treatment.Considering the narrow therapeutic window of oncolytic drugs, this CAM use increases the risk of clinically relevant herb-anticancer drug interactions, therefore leading to substantially more unexpected toxicities of chemotherapeutic drugs and possible undertreatment seen in cancer patients.This review provides information about currently known, clinically relevant PK CAM-drug interactions in oncology and the potential mechanisms.

Key words: herb-drug interactions, chemotherapeutics, induction, inhibition, drug metabolism

CLC Number:

R730.59

FAN Lan, XIE Hai-tang, ZHOU Hong-hao. Herb-drug interactions in oncology and potential mechanisms[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(2): 134-139.

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