Review of new cholesterol absorption inhibitor ezetimibe

Abstract

Abstract: Ezetimibe, a new selective cholesterol absorption inhibitor, may decrease the absorption of cholesterol and plant sterol by inhibiting the cholesterol absorption protein Niemann-Pick C1 like 1 (NPC1L1) in the enterocytes.Ezetimibe apparently reduces the plasma low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) level, which provides a new approach for the therapy of hypercholesterolaemia, artherosclerosis and coronary artery disease.

Key words: ezetimibe, hypercholesterolaemia, cholesterol absorption inhibitor, NPC1L1

CLC Number:

R541.4

ZHANG Xin-bo, WANG Lv-ya. Review of new cholesterol absorption inhibitor ezetimibe[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(3): 258-261.

References

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