Abstract: AIM: To investigate the changes of blood soluble adhesion molecules during hemorrhagic shock in rats and the effects of various of resuscitation fluids on expression of blood cell adhesion molecules in rats with hemorrhagic shock. METHODS: 50 SD rats were divided into 5 (control, sham, shock, lactated Ringer's and 6 % hydroxyethylstarch) groups randomly.Lactated Ringer's group and hydroxye-thylstarch group were subjected to hemorrhagic shock for 1 h, followed by resuscitation with lactated Ringer's solution and 6 % hydroxyethylstarch for 2 h by three times of the lost blood.After resuscitation, the GMP-140, sVCAM-1 and sICAM-1 were measured.At the same time, the control, the shock and the sham groups were drawn the blood to test. RESULTS: Blood plasma GMP-140, sVCAM-1 and sICAM-1 in the shock group were significantly higher than those of the control and sham group (P<0.01).Blood GMP-140, sVCAM-1 and sICAM-1 in Lactated Ringer's group were higher than those of the control group (P<0.01). Plasma GMP-140 in Lactated Ringer's group were higher than that of the sham group (P<0.01).Serum sVCAM-1 in Lactated Ringer's group was higher than that of the shock group (P<0.01).Compared with the shock group and Lactated Ringer's group, the GMP-140, sVCAM-1 and sICAM-1 were reduced in the hydroxyeth-ylstarch group (P<0.01). CONCLUSION: It is concluded that hemorrhagic shock triggers the coagulation cascade reaction, and the coagulation of the actors is greatly consumed.Unbalance of coagulation system plays an important role in the progress of shock.Resuscitation with 6 % hydroxyethylstarch may reduce the inflammatory response in rats undergoing hemorrhagic shock compared to a crystalloid-based volume therapy.Hypothesize that this is most likely due to an improved microcirculation with reduced endothelial activation and less endothelial damage.

Key words: hemorrhagic shock, blood coagulation factor, transfusion therapy, 6 % hydroxyethylstarch, soluble cell adhesion molecules