Abstract: AIM: To study the pharmacokinetics of penciclovir injection in Chinese healthy volunteers. METHODS: 10 healthy volunteers were infused a single dose of 10 mg/kg of penciclovir.The concentrations of penciclovir in plasma and urine were determined by HPLC-FLD.Pharmacokinetic parameters were conformed to a non-compartment model analyzed by WinNonLin program. RESULTS: The main pharmacokinetic parameters were as follows:the ke was (0.37±0.05) h;the t12 was (1.91±0.26)h;the C_max was (9.8±1.6)mg/L; the AUC_0-t was (19.1±2.8)mg·L ^-1 ·h;the AUC_0-∞ was (19.6±2.9)mg·L^-1 ·h;the Vd was (1.4±0.4) L/kg;the CL was (0.52±0.08)L·h·kg ^-1.About 70 %of penciclovir was excreted into urine within 12 h. CONCLUSION: Penciclovir is widely distributed and rapidly excreted, predominantly by the kidney..

Key words: penciclovir, pharmacokinetics, HPLC, determination