Abstract: AIM: To study the effect of garlicin on protecting nonalcoholic fat liver in rats induced by high fat diet and explore the pathogenesis involved. METHODS: According to the dosage of garlicin and diet, fifty SD rats were randomly divided into five equal groups:normal control group, model control group and garlicin (10, 20, 30 mg/kg) groups. Apart from the rats in normal control group, the rats were all fed with high fat and high cholesterol diet. After 12 weeks, the levels of serum endotoxin (ETX) , total cholesterols (TC) , triglyceride (TG) , superoxide dismutase (SOD) , malondialdehyde (MDA ) , transaminase and free fatty acids (FFA) were detected. The levels of MDA, SOD, glutathione hormone (GSH) in hepatic tissue were also detected. Then the features of live pathology were observed. RESULTS: The levels of ETX, TC and TG in garlicin groups were significantly lower than those in model control group (P<0.05 or P<0.01). The SOD and GSH in serum and hepatic tissue of rats treated with garlicin were significantly higher than those in model control group (P<0.05 or P<0.01) ,while the serum MDA and FFA as well asMDA in hepatic tissue were significantly lower than those in model control group (P<0.05, or P<0.01). High dosage of garlicin could alleviate adipose degeneration of hepatic cells compared with low-dose garlicin group (P<0.05). CONCLUSION: Garlicin has high effect of preventing nonalcoholic fat liver disease in a dose-dependent manner. The anti-lipid peroxidation and lowering serum endotoxin effect of garlicin may be the mechanism.

Key words: garlicin, nonalcoholic fat liver disease, lipid preoxidation, endotoxin