Research progress of snake venom disintegrin in treatment of tumor

Abstract

Abstract: The function of cellular membrane receptor has been paid more attention inmany dieases.Integrin is one of them.The major function of integrin is maintaining the proper structure of tissues by organization of cellcell and cell-extracelluar matrix tethering.The initiation and prolongation of many diseases are promoted by these receptors.Disintegrin is one important component of the snake venom.It inhibit the adhesive attraction of integrin particularly.This review summarizes the types and the biological activities of snake venom disintegrins, as well as discusses there potential clinical application of the study, such as anti-tumor, anticoagulation, and various human diseases.

Key words: snake venom, integrin, disintegrin

CLC Number:

R730.5

ZHANG Ye, RUI Jing. Research progress of snake venom disintegrin in treatment of tumor[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(9): 984-988.

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