Abstract: AIM: To evaluate the effect of active peptide from shark livers, S-8300, on beta cell of islet and renal glomeruli cells in alloxan induced diabetic mice.METHODS: The anti-apoptotic effect of S-8300 on diabetic mice was investigated by observing pancreas and kidney cells under electron microscope and DNA electrophoresis.The changes of NO and NOS in serum were also been deteced.RESULTS: The ultrastructural apoptosis lesions in pancreas and kidney cells in S-8300 groups were obviously alleviated and significant decrease of NO and NOS in serum was observed in diabetic mice treated with S-8300.CONCLUSION: The hypoglycemic effects of S-8300 was related with its protective activity against the apoptosis.

Key words: S-8300, diabetes, apoptosis, NO