Abstract: AIM: To investigate the anti-tumor effects of chitosan sulfate in mice. METHODS: 80 mice were divided into control group, 5-FU treatment group and Chitosan sulfate treatment group (200 mg/kg and 100 mg/kg). Different doses of Chitosan were intraperitoneally injected into mice with sarcoma 180 and EAC cancer respectively for 10 days. The tumor inhibiting rate, the weight index of important organ and life prolongation were calculated. RESULTS: The tumor inhibiting rate of high dose, low dose of Chitosan sulfate and 5-FU were 38. 67 %, 30.19 %, 43. 27 %, life prolongation of high dose, low dose of Chitosan sulfate and 5-FU were 65. 38 %, 69. 23 %, 54. 93 %, Compare with control and 5-FU group, the indexes of thymus in high dose and low dose of Chitosan sulfate were significantly increased (P<0.05). CONCLUTIONS: Chitosan sulfate shows significant anti-tumor effects on sarcoma-180 and can prolong the life of mice with EAC cancer. Such effects may be owe to improvement of body immunity.

Key words: chitosan sulfate, anti-tumor, sarcoma-180, EAC cancer