Physiological action of peroxisome proliferator activated receptor γcoactivator-1 and its relationship with type 2 diabetes

Abstract

Abstract: Peroxisome proliferator activated receptorγcoactivator-1 (PGC-1) is one of the coactivators which binds to nuclear receptors or non-nuclear receptor transcription factors and coactivates the transcription and expression of target genes. Some target genes mediated by PGC-1 are vital genes for energy and glucose lipid metabolism and they play very important role in regulation of normal energy balance in human body. Recently, some studies showed that the genetic polymorphisms of PGC-1 were associated with the development of type 2 diabetes, which possibly makes it as a new candidate target gene in the treatment of patients with type 2 diabetes.

Key words: peroxisome proliferator activated receptorγcoactivator-1, genetic polymorphism, energy metabolism

CLC Number:

R587.1

ZHANG Ke-han, LIU Zhao-qian. Physiological action of peroxisome proliferator activated receptor γcoactivator-1 and its relationship with type 2 diabetes[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(1): 6-10.

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