Abstract: AIM: To explore the the value of endothelin, tumor necrosis factor and cyclooxygenase-2 in poisoning related acute mucosal lesion in rats. METHODS: 24 healthy SD rats were randomly divided into four groups as below. the blank control group, the acute methamidophos poison group, the acute methamidophos poison group cured with Omeprazole of normal dose (10 mg/kg), the acute methamidophos poison group cured with Omeprazole of large dose (50 mg/kg). The rat's blood was drawn at 4 hours after model was established. The gastric ulcer index was counted and the content of serum cholinesterase, serum endothelin, blood serum tumor necrosis factor and yclooxygenase-2 expression were measured, and correlation analysis were taken. RESULTS: The correlation of gastric ulcer index and the level of serum endothelin and tumor necrosis factorwere established successfully. There was no obvious correlation between cyclooxygenase-2 expression and gastric ulcer index. CONCLUSION: The serum endothelin and tumor necrosis factor-αincrease in acute poisoning related gstric mucosa injury, so they could be used as monitoring indicators for the advancement and improvements of therapy.

Key words: endothelin, tumor necrosis factor-α, organophosphate poisoning, gastroenteritis, omeprazole