Therapeutic effects of shark hepatic regenerative factor on chronic liver injury in rats

Abstract

Abstract: AIM: The purpose of this study was to evaluate the therapeutic effects of shark hepatic regenerative factor (sHRF) on chronic liver injury in rats.METHODS: Chronic hepatic injury model in rats was induced by Carbon tetrachloride (CCl₄).The activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the content of albumin and total protein in the serum and Hydroxyproline in the liver were measured.RESULTS: Statistics indicated that chronic liver-injured rats with administration for 8 weeks, sHRF could suppress the elevation of ALT, AST in serum andHydroxyproline in liver of liver injury rats induced by CCl₄.There were no significant differences at the dosage of 0.8, 1.6 mg/kg.Moreover, sHRF could increase albumin level and the ratio of albumin and globulin in serum.Hepatic histological findings indicated that sHRF could alleviate liver fibrosis and liver steatosis.CONCLUSION: sHRF had therapeutic effect on chronic liver injury in rats induced by Carbon tetrachloride.

Key words: shark hepatic regenerative factor(sHRF), chronic liver injury, therapeutic effect

CLC Number:

R965

LI Qian, DOU Chang-gui, JIANG Jie, HUANG Fang, WU Wu-tong. Therapeutic effects of shark hepatic regenerative factor on chronic liver injury in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(12): 1350-1354.

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