Effects of paroxetine on the spontaneous behavior and the c-fos expression of hypothalamus paraventricular nucleus in poststroke depression rats

Abstract

Abstract: AIM: To explore the molecular action mechanism of antidepression drug on the poststroke depression (PSD) rats.METHODS: The PSD rat model of focal cerebral ischemia was established by threadtightening middle cerebral artery, followed with restraint stress and isolated breeding.The changes on rats's spontaneous behavior and the expression of c-fos in hypothalamus paraventricular nucleus (PVN), and the effects of paroxetine hydrochloride interference in the PSD rat model were evaluated.RESULTS: Compared with the control group, the consumption of sucrose water, the scores of upright and horizonal activities in the Open-Field test of PSD rats were decreased in significant differences(P <0.01).Compared with the PSD rats, the consumption of sucrose water, the scores of upright and horizonal activities in the drug treatment group increased in significant differences(P <0.01).Compared with the depression group or stroke group, the expressions of c-fos in PVN increased in PSD rats in significant differences (P <0.05).The expression of c-fos in PVN decreased in the drug treatment group, compared with the PSD group, in significant difference.CONCLUSION: The paroxetine could improve the PSD rats depression behavior, which may related with the c-fos decrease expression in the PVN.

Key words: poststroke depression, paraventricular nucleus, immediately-early genes, paroxetine hydrochloride

CLC Number:

R965.2

NI Gui-hua, SHAO Bei, FAN Hong, HUANG Huan-jie. Effects of paroxetine on the spontaneous behavior and the c-fos expression of hypothalamus paraventricular nucleus in poststroke depression rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(12): 1360-1364.

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