Abstract: AIM: To observe the effects of koali vine polysaccharides(STDT) on reducing blood lipids in hyperlipidemic animal model.METHODS: The hyperlipidemic animal model of SD rats, New Zealand rabbits and ICR mice were induced by feeding high cholesterol food and injecting intraperitoneally egg yolk, and then were administered intragastrically with different doses of STDT.The levels of TC, TG, highdensity lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) in serum were measured at different time before and after administration.RESULTS: STDT could restrain the increase of TC, TG and LDL-C in high-lipidmodel rats serum after oral administration for fourweeks at the dosages of 250, 500 and 1000 mg/kg, and degrade the blood fat level of high-lipid model, decrease the levels of TC, TG and LDL-C in rabbits serum obviously at the dosages of 100, 200 and 400 mg/kg.In addition, the high-lipid ICR mice which were administered with STDT for three days showed a decreasing tendency on blood lipids at the dosages of 400, 800, 1600 mg/kg.CONCLUSION: The results suggest that STDT has a reducing blood lipids effects on many high-lipid animal models for prevention or treatment.

Key words: koali vine polysaccharides(STDT), blood lipids, lipid-lowring