Abstract: AIM: To investigate the effects of ganoderma liciudm ploysaccharide (GLP) seleno-κ-carageenan syrups on nonspecific immunity, humoral immunity, cell immunity function of immune suppressed mice induced by cyclophosphamide.METHODS: Immunity hypofunction mouse models were established by intraperitoneal injection of cyclophosphamide (80 mg/kg, o.d.) for 3 days, and ganoderma liciudm ploysaccharide seleno-κ-carageenan syrups were administrated by gastric gavage for 30 days, once a day.The mononuclear phagocyte englobement function, the phagocytosis function(chicken erythrocyte) of abdominal cavity phagocyte, the number of peripheral blood leucocyte, NK cytoactive, interleukin-1 and interleukin-2 activity, TNF-αactivity, serum hemolysin, antibodyproducing cells, increment abilities of T, B lymphocyte delayed allergy were detected.RESULTS: The number of leukocytes, serum hemolysin increased in all 3 groups of ganoderma liciudm ploysaccharide seleno-κ-carageenan syrups(lower dose group:GLP 2.5 mg/kg +Se 5μg kg, medium dose group:GLP 5 mg/kg +Se 10μg kg, high dose group:GLP 15 mg/kg +Se 30μg kg).The activities of IL^-1 in lower dose group, and IL-2 in medium dose group increased.The reproductive activities of T, B lymphocytic cells, NK cytoactive, activity of TNF-αincreased in high group as well as the englobement function of peritoneal macrophage, the carbon particle clearance, antibody-producing cells, delayed allergy.The reproductive activities of T, B lymphocytic cells, NK cytoactive, activity of TNF-αincreased in medium group.CONCLUSION: Ganoderma Liciudm Ploysaccharide seleno-κ-carageenan syrups could improve the immunological function of immunosuppression mice.

Key words: ganoderma liciudm polysaccharide seleno-κ-carageenan syrups, nonspecific immunity, humoral immunity, cell immunity