Research of anti-artery thrombosis mechanism of action and the effect of Xinshi injection on hemorheology in rats

Abstract

Abstract: AIM: To study the anti-artery thrombosis mechanism of action and the effect of Xinshi injection on hemorheological in rats.METHODS: The thrombosis model in mice induced by collagen-adrenalin and the blood stasis model in rats induced by icebath were established, then the impacts of Xinshi injection on thrombogenesis in vivo and in vitro, platelet adhesion rate and hemorheology changes were observed.RESULTS: Each dose of Xinshi injection could obviously reduce the thrombosis of mice in vivo and the platelet adhesion rate of rats.It also improved hemorheology of acute blood stasis rats, inhibited thrombosis of model rats.CONCLUSION: Xinshi injection has significant effects on anti-artery thrombosis and hemorheology of acute blood stasis rats.

Key words: Xinshi injection, thrombogenesis, platelet adhesion rate, hemorheology

CLC Number:

R965.2

XU Peng-fu, KAN Hong-wei, HUANG Shi-fu, YANG Shi-you, CHEN Han. Research of anti-artery thrombosis mechanism of action and the effect of Xinshi injection on hemorheology in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(12): 1392-1395.

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Research of anti-artery thrombosis mechanism of action and the effect of Xinshi injection on hemorheology in rats

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