Abstract: AIM: To investigate the pharmacokinetics of ginkgolide B monomer and extract of ginkgolides in rats.METHODS: The concentrations of ginkgolide B from rats plasma were determined by LCMS method and the pharmacokinetic parameters were calculated using compartment model simulated by 3p87 program.C_max, t_max were expressed as measured.RESULTS: The pharmacokinetic parameters of ginkgolide B and extract in rats after oral administration of monomer were as follows:t_1/2αwas (0.18 ±0.09), (0.17 ± 0.07) h, t_1/2β was (2.3 ±2.0), (2.3 ±1.5) h, AUC_0-12 h was (2701 ± 655), (2889 ± 836)μg°L^-1 °h, AUC_0-∞ was (2778 ±680), (2966 ±854)μg°L^-1 °h, respectively.The oral bioavailability of ginkgolide B in extract was slightly higher than that in monomer.CONCLUSION: There was no significant difference in the pharmacokinetic parameters between ginkgolides B and the extract after oral administration of monomer in rats, and the coexistent substances in ginkgolide extract have no effect on the pharmacokinetic parameters of ginkgolide B in rats.

Key words: ginkgolide B, extract of ginkgolide, pharmacokinetics, LC-MS